申报华夏医学科技奖项目公示

项目名称	肿瘤内长滞留药物系统的构建及在光热治疗中的应用
申报奖项类别	科学技术奖
主要完成单位（含排序）	大连医科大学附属第一医院、复旦大学附属浦东医院
主要完成人（含排序）	郭慧淑、沈顺、蔡正旭、邹堃、刘瑶、欧阳博书、王雪君、苏晓敏、张桂信、李玉春
项目简介：

热疗作为提高放疗敏感性，逆转化疗耐药的重要手段，常与放化疗联合运用于中晚期肿瘤患者治疗中，但传统热疗其靶向性差，受热面积过大，温控精准度不够，反复热疗易引起耐热。

肿瘤治疗光热疗法是借助于光敏剂，将外源性光刺激转化为热能，在肿瘤局部产生高温以达到消除肿瘤的目的。具有高靶向性、高温控性、减小机体创伤等特点，与其它修饰手段并用还可以完美补足耐热问题。本项目以光热疗法为核心，将光热与仿生纳米技术、生物材料体系凝胶载体系统、自由基抗肿瘤等修饰手段相结合，形成体内生物响应调节的多功能给药系统。选用生物相容性和降解性极佳的药用辅料海藻酸钠作为载体，将自由基引发剂（AIPH）和医用墨药（Ink）按一定比例混合，将AIPH与Ink共同包封于原位形成的凝胶体中，有效延长药物肿瘤局部作用时间。在近红外光照射下使Ink产生局部低温刺激，触发AIPH快速分解产生烷基自由基。低温光热治疗和自由基杀伤肿瘤双管齐下，协同辅助化疗，效果显著，该生物响应调节的多功能给药系统完美补足了耐热导致的热疗功效降低，更好地逆转化疗耐药问题，该研究得到国际光热届的关注，已被BM(IF:12.4)和ACS AMI（IF:9.2）接收，部分成果已申请国家专利，是一种安全、可靠、有效提高化疗疗效的新方法。
代表性论文（专著）列表：

1. Boshu Ouyang, Funan Liu, Shuangrong Ruan, Huishu Guo, Zhengxu Cai, Xiangrong Yu, Zhiqing Pang, Shun Shen. Localized free radicals burst triggered by NIR-II light for augmented low-temperature photothermal therapy. ACS Applied Materials & Interfaces.2019, 11(42):38555-38567.

2. Jizong Yao, Yao Liu, Jiawen Wang, Qin Jiang, Dejun She, Huishu Guo, Nianrong Sun, Zhiqing Pang, Chunhui Deng, Wuli Yang, Shun Shen. On-demand CO release for amplification of chemotherapy by MOF functionalized magnetic carbon nanoparticles with NIR irradiation. Biomaterials.2019, 195:51-62.

3.	Xuejun Wang, Haichun Li, Xianping Liu, Ye Tian, Huishu Guo, Ting Jiang, Zimiao Luo, Kai Jin, Xinping Kuai, Yao Liu, Zhiqing Pang, Wuli Yang, Shun Shen. Enhanced photothermal therapy of biomimetic polypyrrole nanoparticles through improving blood flow perfusion. Biomaterials.2017, 143:130-141.

4.	Yao Liu, Xuejun Wang, Boshu Ouyang, Xianping Liu, Yang Du, Xuzheng Cai, Huishu Guo, Zhiqing Pang, Wuli Yang, Shun Shen. Erythrocyte-platelet hybrid membranes coating polypyrrol nanoparticles for enhanced delivery and photothermal therapy. J Mater Chem B.2018, 6(43):7033-7041.

5.	Xiaomin Su, Yongbin Cao, Yao Liu, Boshu Ouyang, Bo Ning, Yang Wang, Huishu Guo, Zhiqing Pang, Shun Shen. Localized disruption of redox homeostasis boosting ferroptosis of tumor by hydrogel delivery system. Mater Today Bio. 2021, 12:100154.

6.	Sheng Wang, Quanjun Lin, Jiantao Chen, Huile Gao, Deliang Fu, Shun Shen. Biocompatible polydopamine-encapsulated gadolinium-loaded carbon nanotubes for MRI and color mapping guided photothermal dissection of tumor metastasis. Carbon.2017, 112:53-62.

7.	Xuejun Wang, Yao Liu, Zhe Liu, Junxiu Hu, Huishu Guo, Fei Wang. Synergistic chemo-photothermal therapy of tumor by hollow carbon nanospheres. Biochem Biophys Res Commun.2018, 495(1):867-872.

8.	Sheng Wang, Qin Zhang, Peng Yang, Xiangrong Yu, Li-Yong Huang, Shun Shen, Sanjun Cai. Manganese oxide-coated carbon nanotubes as dual-modality lymph mapping agents for photothermal therapy of tumor metastasis. ACS Appl Mater Interfaces.2016, 8(6):3736-3743.

9.	Rui Zheng, Sheng Wang, Ye Tian, Xinguo Jiang, Deliang Fu, Shun Shen, Wuli Yang. Polydopamine-coated magnetic composite particles with an enhanced photothermal effect. ACS Appl Mater Interfaces.2015, 7(29):15876-15884.